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Journal Articles Kidney International Year : 2021

Back off to better blow up: acute GFR decrease at SGLT-2 inhibitor initiation

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Abstract

The drop in glomerular filtration rate often observed in the first weeks of nephroprotective treatment, whether because of protein restriction or renin-angiotensin system blockade, can be interpreted as a marker of the relationship between the intensity of baseline glomerular anomalies and the potential treatment benefit. In this issue, Oshima et al. reported a post hoc analysis of the Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation (CREDENCE) study, the results of which confirm that such a relationship is also observed under sodium-glucose cotransporter 2 inhibition in diabetic patients with chronic kidney disease.
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Dates and versions

inserm-03337971 , version 1 (08-09-2021)

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M. Laville. Back off to better blow up: acute GFR decrease at SGLT-2 inhibitor initiation. Kidney International, 2021, 99 (4), pp.814-816. ⟨10.1016/j.kint.2020.12.033⟩. ⟨inserm-03337971⟩
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