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Back off to better blow up: acute GFR decrease at SGLT-2 inhibitor initiation

Abstract : The drop in glomerular filtration rate often observed in the first weeks of nephroprotective treatment, whether because of protein restriction or renin-angiotensin system blockade, can be interpreted as a marker of the relationship between the intensity of baseline glomerular anomalies and the potential treatment benefit. In this issue, Oshima et al. reported a post hoc analysis of the Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation (CREDENCE) study, the results of which confirm that such a relationship is also observed under sodium-glucose cotransporter 2 inhibition in diabetic patients with chronic kidney disease.
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https://www.hal.inserm.fr/inserm-03337971
Contributor : Laboratoire Carmen <>
Submitted on : Wednesday, September 8, 2021 - 12:56:06 PM
Last modification on : Friday, September 10, 2021 - 3:25:02 AM

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M. Laville. Back off to better blow up: acute GFR decrease at SGLT-2 inhibitor initiation. Kidney International, Nature Publishing Group, 2021, 99 (4), pp.814-816. ⟨10.1016/j.kint.2020.12.033⟩. ⟨inserm-03337971⟩

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