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In vivo imaging of EVs in zebrafish: New perspectives from “the waterside”

Abstract : To harmoniously coordinate the activities of all its different cell types, a multicellular organism critically depends on intercellular communication. One recently discovered mode of intercellular cross-talk is based on the exchange of "extracellular vesicles" (EVs). EVs are nano-sized heterogeneous lipid bilayer vesicles enriched in a variety of biomolecules that mediate short- and long-distance communication between different cells, and between cells and their environment. Numerous studies have demonstrated important aspects pertaining to the dynamics of their release, their uptake, and sub-cellular fate and roles in vitro. However, to demonstrate these and other aspects of EV biology in a relevant, fully physiological context in vivo remains challenging. In this review we analyze the state of the art of EV imaging in vivo, focusing in particular on zebrafish as a promising model to visualize, study, and characterize endogenous EVs in real-time and expand our understanding of EV biology at cellular and systems level.
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https://www.hal.inserm.fr/inserm-03336284
Contributor : Clara Martinez Rico <>
Submitted on : Tuesday, September 7, 2021 - 10:22:22 AM
Last modification on : Thursday, September 9, 2021 - 3:11:59 AM

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Vincenzo Verdi, Anaïs Bécot, Guillaume Niel, Frederik Verweij. In vivo imaging of EVs in zebrafish: New perspectives from “the waterside”. FASEB BioAdvances, [Hoboken, NJ] : John Wiley & Sons, Inc., [2019]-, 2021, Online ahead of print. ⟨10.1096/fba.2021-00081⟩. ⟨inserm-03336284⟩

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