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Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies

Abstract : Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5 min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged individual epithelial cells of the mucosal lining with a cellular or subcellular resolution and identified cellular components of the lamina propria. FFOCT represents a promising dye-free imaging tool for on-site analysis of gut tissue remodelling.
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https://www.hal.inserm.fr/inserm-03335659
Contributor : Elizabeth Bernardo <>
Submitted on : Monday, September 6, 2021 - 1:52:38 PM
Last modification on : Wednesday, September 15, 2021 - 3:03:24 AM

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Lucille Quénéhervé, Raphael Olivier, Michalina Gora, Céline Bossard, Jean-François Mosnier, et al.. Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies. Gut, BMJ Publishing Group, 2020, 70 (1), pp.6 - 8. ⟨10.1136/gutjnl-2020-321228⟩. ⟨inserm-03335659⟩

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