Skip to Main content Skip to Navigation
Journal articles

Ethinylestradiol (EE2) residues from birth control pills impair nervous system development and swimming behavior of zebrafish larvae

Abstract : The ubiquitous use of ethinylestradiol (EE2), an active constituent of birth control preparations, results in continuous release of this synthetic estrogen to surface waters. Many studies document the untoward effects of EE2 on the endocrine system of aquatic organisms. Effects of environmental EE2 on the nervous system are still poorly documented. We studied effects of pico- to nanomolar concentrations of EE2 on early nervous system development of zebrafish larvae. EE2 disrupted axonal nerve regeneration and hair cell regeneration up to 50%. Gene expression in larval brain tissues showed significantly upregulated expression of target genes, such as estrogen and progesterone receptors, and aromatase B. In contrast, downregulation of the tyrosine hydroxylase, involved in the synthesis of neurotransmitters, occurred concomitant with diminution of proliferating cells. Overall, the size of exposed fish larvae decreased by 25% and their swimming behavior was modified compared to non-treated larvae. EE2 interferes with nervous system development, both centrally and peripherally, with negative effects on regeneration and swimming behavior. Survival of fish and other aquatic species may be at risk in chronically EE2-contaminated environments.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03334060
Contributor : Veronique Perrier <>
Submitted on : Friday, September 3, 2021 - 2:10:11 PM
Last modification on : Wednesday, September 15, 2021 - 11:30:15 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Ahmed Nasri, Ali Mezni, Pierre-André Lafon, Aymen Wahbi, Nicolas Cubedo, et al.. Ethinylestradiol (EE2) residues from birth control pills impair nervous system development and swimming behavior of zebrafish larvae. Science of the Total Environment, Elsevier, 2021, 770, pp.145272. ⟨10.1016/j.scitotenv.2021.145272⟩. ⟨inserm-03334060⟩

Share

Metrics

Record views

6