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PPAR control of metabolism and cardiovascular functions

Abstract : Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription factors that regulate gene expression following ligand activation. PPARα increases cellular fatty acid uptake, esterification and trafficking and regulates lipoprotein metabolism genes. PPARδ stimulates lipid and glucose utilization by increasing mitochondrial function and fatty acid desaturation pathways. By contrast, PPARγ promotes fatty acid uptake, triglyceride formation and storage in lipid droplets, thereby improving insulin sensitivity and glucose metabolism. PPARs also exert anti-atherogenic and anti-inflammatory effects on the vascular wall and immune cells. Clinically, PPARγ activation by glitazones and PPARα activation by fibrates improve insulin resistance and dyslipidaemia, respectively. PPARs are also physiological master switches in the heart, steering cardiac energy metabolism in cardiomyocytes, thereby affecting pathological heart failure and diabetic cardiomyopathy. Novel PPAR agonists in clinical development are providing new opportunities in the management of metabolic and cardiovascular diseases.
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Contributor : Marie-Hélène Derudas Connect in order to contact the contributor
Submitted on : Tuesday, August 17, 2021 - 1:21:51 PM
Last modification on : Friday, April 1, 2022 - 3:49:14 AM
Long-term archiving on: : Thursday, November 18, 2021 - 6:37:36 PM




David Montaigne, Laura Butruille, Bart Staels. PPAR control of metabolism and cardiovascular functions. Nature Reviews Cardiology, Nature Publishing Group, 2021, Online ahead of print. ⟨10.1038/s41569-021-00569-6⟩. ⟨inserm-03321273⟩



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