Skip to Main content Skip to Navigation
Journal articles

Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics

Abstract : We recently identified a previously unappreciated ability of antimitotics to propagate apoptotic priming across cancer cell populations. The underlying paracrine cytotoxic signal, fueled by undead cells activating the cGAS/STING pathway, is required for in vivo antitumor response and it can be further exploited by delayed, but not synchronous, BCL-xL inhibition.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03319352
Contributor : Sophie Barillé-Nion Connect in order to contact the contributor
Submitted on : Thursday, August 12, 2021 - 11:04:11 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:38 AM

Links full text

Identifiers

`

Citation

Steven Lohard, Philippe Juin, Sophie Barillé-Nion. Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics. Molecular & Cellular Oncology, Taylor et Francis, 2020, 7 (3), pp.1735912. ⟨10.1080/23723556.2020.1735912⟩. ⟨inserm-03319352⟩

Share

Metrics

Record views

14