Skip to Main content Skip to Navigation
Journal articles

Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors

Abstract : Duodenopancreatic neuroendocrine tumors (DPNETs) aggressiveness is heterogeneous. Tumor grade and extension are commonly used for prognostic determination. Yet, grade classes are empirically defined, with regular updates changing the definition of classes. Genomic screening may provide more objective classes and reflect tumor biology. The aim of this study was to provide a transcriptome classification of DPNETs. We included 66 DPNETs, covering the entire clinical spectrum of the disease in terms of secretion, grade, and stage. Three distinct molecular groups were identified, associated with distinct outcomes (log-rank P < 0.01): (i) better-outcome DPNETs with pancreatic beta-cell signature. This group was mainly composed of well-differentiated, grade 1 insulinomas; (ii) poor-outcome DPNETs with pancreatic alpha-cell and hepatic signature. This group included all neuroendocrine carcinomas and grade 3 DPNETs, but also some grade 1 and grade 2 DPNETs and (iii) intermediate-outcome DPNETs with pancreatic exocrine and progenitor signature. This group included grade 1 and grade 2 DPNETs, with some insulinomas. Fibrinogen gene FGA expression was one of the topmost expressed liver genes. FGA expression was associated with disease-free survival (HR = 1.13, P = 0.005) and could be validated on two independent cohorts. This original pathophysiologic insight provides new prognostic classification perspectives.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03312405
Contributor : Sylvaine You Connect in order to contact the contributor
Submitted on : Monday, August 2, 2021 - 1:03:06 PM
Last modification on : Tuesday, September 28, 2021 - 5:15:04 PM

Identifiers

Collections

Citation

Marc Diedisheim, Solène Dermine, Anne Jouinot, Amandine Septier, Sébastien Gaujoux, et al.. Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors. Endocrine-Related Cancer, BioScientifica, 2021, 28 (8), pp.563-571. ⟨10.1530/ERC-21-0051⟩. ⟨inserm-03312405⟩

Share

Metrics

Record views

32