Skip to Main content Skip to Navigation
Journal articles

Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”

Abstract : Among all existing radionuclides, only a few are of interest for therapeutic applications and more specifically for targeted alpha therapy (TAT). From this selection, actinium-225, astatine-211, bismuth-212, bismuth-213, lead-212, radium-223, terbium-149 and thorium-227 are considered as the most suitable. Despite common general features, they all have their own physical characteristics that make them singular and so promising for TAT. These radionuclides were largely studied over the last two decades, leading to a better knowledge of their production process and chemical behavior, allowing for an increasing number of biological evaluations. The aim of this review is to summarize the main properties of these eight chosen radionuclides. An overview from their availability to the resulting clinical studies, by way of chemical design and preclinical studies is discussed.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03292397
Contributor : François Guérard <>
Submitted on : Tuesday, July 20, 2021 - 2:14:48 PM
Last modification on : Friday, July 30, 2021 - 10:22:19 AM

File

Eychenne et al. - 2021 - Overv...
Publisher files allowed on an open archive

Identifiers

Citation

Romain Eychenne, Michel Chérel, Férid Haddad, François Guérard, Jean-François Gestin. Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”. Pharmaceutics, MDPI, 2021, 13 (6), pp.906. ⟨10.3390/pharmaceutics13060906⟩. ⟨inserm-03292397⟩

Share

Metrics

Record views

44

Files downloads

132