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Role of IL-12 in overcoming the low responsiveness of NK cells to missing self after traumatic brain injury

Abstract : Blood samples from 32 patients with severe Traumatic brain injury (TBI) were studied and compared with 11 cardiac surgery patients, and 29 healthy controls. A dramatic decreased expression of HLA class I molecules on monocytes was associated with increased KIR+ NK cell frequency in TBI patients. Overall, the phenotype of TBI NK cells marked by KIR and CD57 expression and lower level of NKp46 and DNAM-1 reflected a differentiated state. The NK-cell response to missing self was marked by lower degranulation and lower IFN-γ production after stimulation with HLA class I deficient cell line. In contrast, the NK-cell ADCC was not altered. IL-12 was able to restore both IFN-γ production and the cytotoxicity capacities of NK cells. This study provides the first extensive description of the phenotype and functions of NK cells in TBI patients. Further evaluation of IL-12 treatment to overcome immunosuppression-induced nosocomial infections is warranted.
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https://www.hal.inserm.fr/inserm-03291141
Contributor : Christelle Retiere Connect in order to contact the contributor
Submitted on : Monday, July 19, 2021 - 4:26:24 PM
Last modification on : Wednesday, July 28, 2021 - 3:24:11 AM
Long-term archiving on: : Wednesday, October 20, 2021 - 7:14:58 PM

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Antoine Roquilly, Gaëlle David, Raphael Cinotti, Mickaël Vourc'H, Helene Morin, et al.. Role of IL-12 in overcoming the low responsiveness of NK cells to missing self after traumatic brain injury. Clinical Immunology, Elsevier, 2015, 177, pp.87 - 94. ⟨10.1016/j.clim.2015.08.006⟩. ⟨inserm-03291141⟩

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