Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission - Archive ouverte HAL Access content directly
Journal Articles Cytometry Part A Year : 2021

Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission

(1, 2) , (1, 2, 3) , (1, 2) , (3, 1, 2) , (1, 2) , (1, 2, 3) , (1, 4) , (1, 2) , (1, 2, 3) , (1, 2, 5) , (1, 2, 3)
1
2
3
4
5

Abstract

During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.
Embargoed file
Embargoed file
Ne sera jamais visible

Dates and versions

inserm-03282704 , version 1 (09-07-2021)

Identifiers

Cite

M. Ortillon, R. Coudereau, M. Cour, T. Rimmele, M. Godignon, et al.. Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission. Cytometry Part A, 2021, 99 (5), pp.466-471. ⟨10.1002/cyto.a.24315⟩. ⟨inserm-03282704⟩
39 View
22 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More