Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission

M. Ortillon; R. Coudereau; M. Cour; T. Rimmele; M. Godignon; M. Gossez; H. Yonis; L. Argaud; A. C. Lukaszewicz; F. Venet; G. Monneret

doi:10.1002/cyto.a.24315

Journal articles

Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission

M. Ortillon ^{1, 2} R. Coudereau ^{1, 2, 3} M. Cour ^{1, 2} T. Rimmele ^{3, 1, 2} M. Godignon ^{1, 2} M. Gossez ^{1, 2, 3} H. Yonis ^{1, 4} L. Argaud ^{1, 2} A. C. Lukaszewicz ^{1, 2, 3} F. Venet ^{1, 2, 5} G. Monneret ^{1, 2, 3}

1 HCL - Hospices Civils de Lyon

2 Hôpital Edouard Herriot [CHU - HCL]

3 PI3 - Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques - EA 7426

4 Hôpital de la Croix-Rousse [CHU - HCL]

5 NLRP3 - Inflammasome NLRP3 et réponse immunitaire au sepsis - NLRP3 inflammasome and immune response to sepsis

CIRI - Centre International de Recherche en Infectiologie - UMR

Abstract : During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.

Keywords : sepsis Covid-19 Cd169 monocyte

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadata

https://www.hal.inserm.fr/inserm-03282704
Contributor : Laboratoire Carmen <>
Submitted on : Friday, July 9, 2021 - 1:18:10 PM
Last modification on : Friday, July 16, 2021 - 3:17:55 AM

Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission

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Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission

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