Skip to Main content Skip to Navigation
Journal articles

Specific contribution of neurons from the Dbx1 lineage to the piriform cortex

Abstract : The piriform cortex (PC) is a major cortical processing center for the sense of smell that receives direct inputs from the olfactory bulb. In mice, the PC consists of three neuronal layers, which are populated by cells with distinct developmental origins. One origin of PC neurons is the pool of Dbx1-expressing neural progenitors located in the ventral pallium at the pallial-subpallial boundary. Since the precise mechanisms of PC neuron development are largely unknown, we sought to define the distribution, timing of neurogenesis, morphology and projection patterns of PC neurons from the Dbx1 lineage. We found that Dbx1-lineage neurons are preferentially distributed in layer 2 and enriched in the ventral portion of the PC. Further, Dbx1 neurons are early-born neurons and contribute to most neuronal subtypes in the PC. Our data also revealed an enrichment of Dbx1-lineage neurons in the ventral anterior PC that project to the orbitofrontal cortex. These findings suggest a specific association between the developmental origin of PC neurons and their neuronal properties.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03280599
Contributor : Clara Martinez Rico Connect in order to contact the contributor
Submitted on : Wednesday, July 7, 2021 - 2:38:31 PM
Last modification on : Tuesday, October 19, 2021 - 11:42:11 AM
Long-term archiving on: : Friday, October 8, 2021 - 6:39:43 PM

File

Shabangu et al Sci Rep. 2021.p...
Publication funded by an institution

Identifiers

Collections

Citation

Thando Shabangu, Hung-Lun Chen, Zi-Hui Zhuang, Alessandra Pierani, Chien-Fu F Chen, et al.. Specific contribution of neurons from the Dbx1 lineage to the piriform cortex. Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.8349. ⟨10.1038/s41598-021-86512-8⟩. ⟨inserm-03280599⟩

Share

Metrics

Record views

12

Files downloads

26