Skip to Main content Skip to Navigation
Journal articles

Safety and efficacy of pazopanib as a second-line treatment and beyond for soft tissue sarcomas: A real-life tertiary-center experience in the MENA region

Abstract : INTRODUCTION: Sarcomas are uncommon malignancies. No advances have been recently achieved despite multiple efforts. Pazopanib is a safe and effective tyrosine kinase inhibitor used in managing soft tissue sarcomas (STS) after chemotherapy failure. However, its use is limited in developing countries and no efficacy data exist from our region. We aimed to study the efficacy of pazopanib in our population, characterized by response rates of patients with chemotherapy-refractory advanced STS receiving pazopanib. Secondary endpoints included progression-free survival (PFS), overall survival (OS) and toxicity profile. MATERIALS AND METHODS: 15 patients (age≥18 year) diagnosed with advanced STS, refractory to first-line chemotherapy, receiving pazopanib as ≥second-line therapy in one tertiary center in Lebanon were included between January 1st, 2014 and October 31st, 2018. Patient and disease characteristics, disease evaluation, as well as tolerance to treatment, were extracted from charts retrospectively. Statistical analysis was done using SPSS version 24. RESULTS: The mean age was 48.6 [19-66] years. Eleven patients (73.3%) received pazopanib in second-line, whereas four patients (26.7%) received it in third-line. Thirteen patients (86.7%) progressed, and two patients (13.3%) had stable disease. The median PFS was three months [1-19] and the mean OS was 25.4 months [17.2-33.6]. Five patients required dose-reductions due to poor tolerance. CONCLUSION: Conclusions cannot be drawn due to small patient numbers. However, given the 3-month PFS, 13% of patients maintaining stable disease, and tolerable safety profile, it is reasonable to incorporate pazopanib in STS treatment. More focused studies with larger patient populations need to be done in Lebanon.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03274427
Contributor : Laboratoire Carmen <>
Submitted on : Wednesday, June 30, 2021 - 9:55:18 AM
Last modification on : Friday, July 2, 2021 - 3:30:41 AM

File

1-s2.0-S2468294220301106-main....
Publication funded by an institution

Identifiers

Collections

Citation

N. A. Halim, R. E. Sayed, I. A. Alameh, J. Khoury, C. E. Nakib, et al.. Safety and efficacy of pazopanib as a second-line treatment and beyond for soft tissue sarcomas: A real-life tertiary-center experience in the MENA region. Cancer Treatment and Research Communications, [London] : Elsevier, [2016]-, 2021, 26, pp.100275. ⟨10.1016/j.ctarc.2020.100275⟩. ⟨inserm-03274427⟩

Share

Metrics

Record views

11

Files downloads

9