Skip to Main content Skip to Navigation
Journal articles

Evolution of body composition and wasting indicators by time of day of haemodialysis

Abstract : BACKGROUND: It has been a long-standing clinical concern that haemodialysis (HD) patients on afternoon shifts (ASs) are more prone to protein-energy wasting (PEW) than those on morning shifts (MSs), as their dialysis scheme and post-dialysis symptoms may interfere with meal intake. We evaluated the effect of time of day of HD on the evolution of body composition changes and PEW surrogates. METHODS: We conducted a retrospective study among 9.963 incident HD patients treated in NephroCare centres (2011-16); data were routinely collected in the European Clinical Database. The course of multi-frequency bioimpedance determined lean and fat tissue indices (LTI and FTI) between patients in MSs/ASs over 2 years were compared with linear mixed models. Secondary PEW indicators were body mass index, albumin, creatinine index and normalized protein catabolic rate. Models included fixed (age, sex, vascular access and diabetes mellitus) and random effects (country and patient). RESULTS: Mean baseline LTI and FTI were comparable between MSs (LTI: 12.5 ± 2.9 kg/m2 and FTI: 13.7 ± 6.0 kg/m2) and ASs (LTI: 12.4 ± 2.9 kg/m2 and FTI: 13.2 ± 6.1 kg/m2). During follow-up, LTI decreased and FTI increased similarly, with a mean absolute change (baseline to 24 months) of -0.3 kg/m2 for LTI and +1.0 kg/m2 for FTI. The course of these malnutrition indicators did not differ between dialysis shifts (P for interaction ≥0.10). We also did not observe differences between groups for secondary PEW indicators. CONCLUSIONS: This study suggests that a dialysis shift in the morning or in the afternoon does not impact the long-term nutritional status of HD patients. Regardless of time of day of HD, patients progressively lose muscle mass and increase body fat.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03274419
Contributor : Laboratoire Carmen Connect in order to contact the contributor
Submitted on : Wednesday, June 30, 2021 - 9:54:56 AM
Last modification on : Monday, October 11, 2021 - 1:24:20 PM
Long-term archiving on: : Friday, October 1, 2021 - 6:11:55 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

J. J. Carrero, A. M. Zawada, M. Wolf, S. Stuard, B. Canaud, et al.. Evolution of body composition and wasting indicators by time of day of haemodialysis. Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2021, 36 (2), pp.346-354. ⟨10.1093/ndt/gfaa253⟩. ⟨inserm-03274419⟩

Share

Metrics

Record views

23