Skip to Main content Skip to Navigation
Journal articles

Starch digestibility modulation significantly improves glycemic variability in type 2 diabetic subjects: A pilot study

Abstract : BACKGROUND AND AIMS: In type 2 diabetes (T2D) patients, the reduction of glycemic variability and postprandial glucose excursions is essential to limit diabetes complications, beyond HbA1c level. This study aimed at determining whether increasing the content of Slowly Digestible Starch (SDS) in T2D patients' diet could reduce postprandial hyperglycemia and glycemic variability compared with a conventional low-SDS diet. METHODS AND RESULTS: For this randomized cross-over pilot study, 8 subjects with T2D consumed a controlled diet for one week, containing starchy products high or low in SDS. Glycemic variability parameters were evaluated using a Continuous Glucose Monitoring System. Glycemic variability was significantly lower during High-SDS diet compared to Low-SDS diet for MAGE (Mean Amplitude of Glycemic Excursions, p \textless 0.01), SD (Standard Deviation, p \textless 0.05), and CV (Coefficient of Variation, p \textless 0.01). The TIR (Time In Range) [140-180 mg/dL[ was significantly higher during High-SDS diet (p \textless 0.0001) whereas TIRs ≥180 mg/dL were significantly lower during High-SDS diet. Post-meals tAUC (total Area Under the Curve) were significantly lower during High-SDS diet. CONCLUSION: One week of High-SDS Diet in T2D patients significantly improves glycemic variability and reduces postprandial glycemic excursions. Modulation of starch digestibility in the diet could be used as a simple nutritional tool in T2D patients to improve daily glycemic control. REGISTRATION NUMBER: in NCT03289494.
Document type :
Journal articles
Complete list of metadata
Contributor : laboratoire CarMeN Connect in order to contact the contributor
Submitted on : Wednesday, June 30, 2021 - 9:54:54 AM
Last modification on : Thursday, November 25, 2021 - 4:11:14 PM
Long-term archiving on: : Friday, October 1, 2021 - 6:11:45 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document



A. E. Breyton, A. Goux, S. Lambert-Porcheron, A. Meynier, M. Sothier, et al.. Starch digestibility modulation significantly improves glycemic variability in type 2 diabetic subjects: A pilot study. Nutrition, Metabolism and Cardiovascular Diseases, Elsevier, 2021, 31 (1), pp.237-246. ⟨10.1016/j.numecd.2020.08.010⟩. ⟨inserm-03274418⟩



Record views