Skip to Main content Skip to Navigation
Journal articles

Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells

Abstract : Structured abstract Background & aim: Resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (CRC) is frequent and prognostic biomarkers are lacking. MicroRNAs (miR) are good candidates in this context. We aimed to characterize cetuximab and panitumumab exposure influence on miR expression in colorectal cancer cells to identify those regulating the EGFR pathway and implicated in resistance to treatment. Finally, we aimed to identify miR expression in serum of patients with advanced CRC treated with cetuximab or panitumumab. Results: Cetuximab and panitumumab exposure induced significant expression variations of 17 miR out of a miRnome panel of 752. Six of those miR interacted with at least one downstream element of the EGFR pathway. Conclusion: After the bioinformatics two-phase process, 5 miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. In vivo, we detected the expression of miR-139-5p and miR-145-5p in serum of patients with metastatic CRC.
Complete list of metadata

https://www.hal.inserm.fr/inserm-03272360
Contributor : William Raoul Connect in order to contact the contributor
Submitted on : Monday, June 28, 2021 - 12:01:00 PM
Last modification on : Saturday, September 25, 2021 - 11:40:03 AM
Long-term archiving on: : Wednesday, September 29, 2021 - 7:03:41 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-12-25

Please log in to resquest access to the document

Identifiers

Citation

Romain Chautard, Laetitia Corset, Sajida Ibrahim, Céline Desvignes, Gilles Paintaud, et al.. Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells. Biomarkers in Medicine, Future Medicine, 2021, Online ahead of print. ⟨10.2217/bmm-2020-0520⟩. ⟨inserm-03272360⟩

Share

Metrics

Record views

66