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Osteomorphs as a tool for personalized medicine

Guillaume Mabilleau 1, 2 Hélène Libouban 1 Valérie Geoffroy 3, 4, 5
1 GEROM - Groupe d'Études Remodelage Osseux et bioMatériaux
2 CHU Angers - Centre Hospitalier Universitaire d'Angers
3 RMeS - Regenerative Medicine and Skeleton research lab
4 UN - Université de Nantes
5 ONIRIS - Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique
Abstract : McDonald and colleagues reported osteoclast-related dynamic mechanisms that lead, by fission, to osteomorphs; motile, fusion-competent cells capable of forming bone-resorbing osteoclasts. scRNA-seq analyses revealed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and might be implicated in rare and common bone diseases in humans.
Keywords : bone resorption osteoclast osteomorphs
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https://www.hal.inserm.fr/inserm-03269575
Contributor : Arnaud Eyraud <>
Submitted on : Thursday, June 24, 2021 - 10:40:58 AM
Last modification on : Friday, August 6, 2021 - 8:44:57 AM

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INSERM | UNAM | UNIV-NANTES | UNIV-ANGERS | GEROM | RMES

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Guillaume Mabilleau, Hélène Libouban, Valérie Geoffroy. Osteomorphs as a tool for personalized medicine. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , Elsevier, 2021, pp.S1043-2760(21)00076-X. ⟨10.1016/j.tem.2021.04.004⟩. ⟨inserm-03269575⟩

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