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Osteomorphs as a tool for personalized medicine

Abstract : McDonald and colleagues reported osteoclast-related dynamic mechanisms that lead, by fission, to osteomorphs; motile, fusion-competent cells capable of forming bone-resorbing osteoclasts. scRNA-seq analyses revealed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and might be implicated in rare and common bone diseases in humans.
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Submitted on : Thursday, June 24, 2021 - 10:40:58 AM
Last modification on : Wednesday, April 27, 2022 - 4:03:45 AM
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Guillaume Mabilleau, Hélène Libouban, Valérie Geoffroy. Osteomorphs as a tool for personalized medicine. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , Elsevier, 2021, pp.S1043-2760(21)00076-X. ⟨10.1016/j.tem.2021.04.004⟩. ⟨inserm-03269575⟩



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