Role of mitochondria in liver metabolic health and diseases - Archive ouverte HAL Access content directly
Journal Articles Cell Calcium Year : 2021

Role of mitochondria in liver metabolic health and diseases

(1) , (1) , (2) , (1)
1
2

Abstract

The liver is a major organ that coordinates the metabolic flexibility of the whole body, which is characterized by the ability to adapt dynamically in response to fluctuations in energy needs and supplies. In this context, hepatocyte mitochondria are key partners in fine-tuning metabolic flexibility. Here we review the metabolic and signalling pathways carried by mitochondria in the liver, the major pathways that regulate mitochondrial function and how they function in health and metabolic disorders associated to obesity, i.e. insulin resistance, non-alcoholic steatosis and steatohepatitis and hepatocellular carcinoma. Finally, strategies targeting mitochondria to counteract liver disorders are discussed.
Embargoed file
Embargoed file
Ne sera jamais visible

Dates and versions

inserm-03269075 , version 1 (23-06-2021)

Identifiers

Cite

B. Morio, B. Panthu, A. Bassot, J. Rieusset. Role of mitochondria in liver metabolic health and diseases. Cell Calcium, 2021, 94, pp.102336. ⟨10.1016/j.ceca.2020.102336⟩. ⟨inserm-03269075⟩
19 View
21 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More