Tumor Vessels Fuel the Fire in Glioblastoma - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

Tumor Vessels Fuel the Fire in Glioblastoma

Résumé

Glioblastoma, a subset of aggressive brain tumors, deploy several means to increase blood vessel supply dedicated to the tumor mass. This includes typical program borrowed from embryonic development, such as vasculogenesis and sprouting angiogenesis, as well as unconventional processes, including co-option, vascular mimicry, and transdifferentiation, in which tumor cells are pro-actively engaged. However, these neo-generated vascular networks are morphologically and functionally abnormal, suggesting that the vascularization processes are rather inefficient in the tumor ecosystem. In this review, we reiterate the specificities of each neovascularization modality in glioblastoma, and, how they can be hampered mechanistically in the perspective of anti-cancer therapies.
Fichier principal
Vignette du fichier
ijms-22-06514(1).pdf (3.08 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

inserm-03265068 , version 1 (18-06-2021)

Identifiants

Citer

Sara Rosińska, Julie Gavard. Tumor Vessels Fuel the Fire in Glioblastoma. International Journal of Molecular Sciences, 2021, 22 (12), pp.6514. ⟨10.3390/ijms22126514⟩. ⟨inserm-03265068⟩
51 Consultations
103 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More