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A Fresh Perspective on Monoclonal Gammopathies of Renal Significance

Abstract : Monoclonal gammopathies of renal significance (MGRS) encompass a remarkable variety of kidney diseases that result from intrinsic nephrotoxic properties of certain monoclonal Igs or their subunits. Effective disease-modifying treatments rely on the targeting of a malignant B-cell clone that may be demonstrable but often is quite hypothetical. Hence, convincing arguments for the genuine monoclonal character of the causative mono-isotypic Ig tissue deposits is needed for design of appropriate treatment strategies. The purpose of this article was to critically analyze distinct situations of suspected MGRS that occur in the practice of pathologists, nephrologists, hematologists, and immunologists. A particular focus of interest is the group of conditions known as proliferative glomerulonephritis with mono-isotypic immunoglobulin deposits (PGNMIDs), which illustrates the difficulties and ambiguities surrounding a definitive assignment of MGRS status.
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Contributor : Pierre Aucouturier Connect in order to contact the contributor
Submitted on : Tuesday, June 15, 2021 - 4:41:41 PM
Last modification on : Wednesday, February 2, 2022 - 10:42:05 AM
Long-term archiving on: : Thursday, September 16, 2021 - 7:02:16 PM


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Pierre Aucouturier, Vivette D D’agati, Pierre Ronco. A Fresh Perspective on Monoclonal Gammopathies of Renal Significance. Kidney International Reports, Elsevier, 2021, Online ahead of print. ⟨10.1016/j.ekir.2021.04.026⟩. ⟨inserm-03261414⟩



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