Abstract : Despite their high sequence homology, the peptide neurotoxins ¢o-conotoxin MVIIA and MVIIC selectively block N-and P/Q-type calcium channels, respectively. To study the recognition mechanism of calcium channel subtypes, two chimeric analogs of ¢o-conotoxin MVIIA and MVIIC were synthesized by exchanging their N-and C-terminal halves. Binding assay for both N-and P/Q-type calcium channels showed that amino acid residues restricted to the N-terminal half are important for the recognition of N-type channels, whereas essential residues for P/Q-type channel recognition are widely spread over the whole ¢o-conotoxin molecule.
https://www.hal.inserm.fr/inserm-03246882 Contributor : Cécile RaymondConnect in order to contact the contributor Submitted on : Wednesday, June 2, 2021 - 4:23:04 PM Last modification on : Friday, January 28, 2022 - 3:43:12 AM Long-term archiving on: : Friday, September 3, 2021 - 7:47:26 PM
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