The role of host autophagy machinery in controlling Toxoplasma infection - Archive ouverte HAL Access content directly
Journal Articles Virulence Year : 2018

The role of host autophagy machinery in controlling Toxoplasma infection

(1)
1

Abstract

Toxoplasma gondii is an obligate intracellular parasitic protist that infects a wide range of warm-blooded vertebrates. Although this parasite can cause serious complications, infections are often asymptomatic, allowing T. gondii to persist in its host and possibly enhancing the chances of its transmission. T. gondii has thus evolved multiple mechanisms of host manipulation to establish chronic infection. This persistence involves a balance between host immunity and parasite evasion of this immune response. This review highlights recent investigations that have demonstrated the important role played by the autophagy machinery in this balance, both in parasite control by the host, and in host exploitation by the parasite.
Fichier principal
Vignette du fichier
Besteiro-Virulence-2018.pdf (1.75 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

inserm-03245217 , version 1 (01-06-2021)

Identifiers

Cite

Sébastien Besteiro. The role of host autophagy machinery in controlling Toxoplasma infection. Virulence, 2018, 10 (1), pp.438 - 447. ⟨10.1080/21505594.2018.1518102⟩. ⟨inserm-03245217⟩
19 View
30 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More