Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1 - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue eLife Année : 2021

Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

Résumé

The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is unknown. Using transgenic mice, we found that SuM axon stimulation elicited mixed excitatory and inhibitory responses in area CA2 pyramidal neurons (PNs). Parvalbumin-expressing basket cells were largely responsible for the feedforward inhibitory drive of SuM over area CA2. Inhibition recruited by the SuM input onto CA2 PNs increased the precision of action potential firing both in conditions of low and high cholinergic tone. Furthermore, SuM stimulation in area CA2 modulated CA1 activity, indicating that synchronized CA2 output drives a pulsed inhibition in area CA1. Hence, the network revealed here lays basis for understanding how SuM activity directly acts on the local hippocampal circuit to allow social memory encoding.
Fichier principal
Vignette du fichier
Robert_etal_eLife2021preprint.pdf (5.01 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

inserm-03239710 , version 2 (27-05-2021)
inserm-03239710 , version 1 (21-10-2021)

Identifiants

Citer

Vincent Robert, Ludivine Therreau, Vivien Chevaleyre, Eude Lepicard, Cécile Viollet, et al.. Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1. eLife, 2021, 10, ⟨10.7554/eLife.63352⟩. ⟨inserm-03239710v1⟩
47 Consultations
53 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More