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Cytokine changes in sickle-cell disease patients as markers predictive of the onset of delayed hemolytic transfusion reactions

Abstract : Background: Changes in cytokine production are known to contribute to the pathogenesis of sickle-cell disease (SCD), particularly in painful acute complications (crises) and episodes of post-transfusion hemolysis. Little is known about cytokine profiles in patients with these complications. Study design and methods: We investigated possible associations between cytokine profile and the onset of delayed hemolytic transfusion reactions (DHTRs), particularly during acute-phase episodes, to improve characterization of the biological parameters predictive of such events. We included SCD patients with severe acute symptoms (n = 36) or steady-state disease (n = 31), both possibly leading to a DHTR (n = 18) event. Luminex® technology was used to determine the plasma concentrations of 23 cytokines. Results: Regardless of clinical context, the concentrations of interleukin (IL)-6, IL-10, inducible protein-10, and macrophage inflammatory protein-1β were higher in plasma samples from SCD patients than in those from healthy controls. IL-6 and IL-10 concentrations were even higher in acute-phase plasma samples from SCD patients. In addition, IL-27 and TNFα levels were higher, and IL-6 and RANTES levels were lower in acute-phase SCD patients just before the onset of DHTR than in patients experiencing painful occlusive episodes. Conclusion: In addition to reporting the plasma cytokine profiles of SCD patients in various clinical phases of the disease, we provide the first evidence of a significant association between low plasma TNFα concentration, high plasma IP-10 concentration and the onset of DHTR in SCD patients.
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https://www.hal.inserm.fr/inserm-03238569
Contributor : Philippe Chadebech Connect in order to contact the contributor
Submitted on : Thursday, May 27, 2021 - 10:42:34 AM
Last modification on : Tuesday, September 28, 2021 - 5:16:45 PM

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Philippe Chadebech, Marie-Amélie de Ménorval, Gwellaouen Bodivit, Alicia Jouard, Sadaf Pakdaman, et al.. Cytokine changes in sickle-cell disease patients as markers predictive of the onset of delayed hemolytic transfusion reactions. Cytokine, Elsevier, 2020, 136, pp.155259. ⟨10.1016/j.cyto.2020.155259⟩. ⟨inserm-03238569⟩

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