Positive predictive values of CMV-IgM and importance of CMV-IgG avidity testing in detecting primary infection in three different clinical settings. A French retrospective cohort study - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Virology Year : 2020

Positive predictive values of CMV-IgM and importance of CMV-IgG avidity testing in detecting primary infection in three different clinical settings. A French retrospective cohort study

(1, 2) , (1) , (1) , (1) , (3) , (1, 3)
1
2
3

Abstract

Background: Diagnosis of Cytomegalovirus (CMV) primary infection during pregnancy or in immunocompetent patients relies on serology with detection of specific CMV-IgG and IgM. In case of positive CMV-IgM in pregnant women, CMV-IgG avidity is now widely recommended, but in general population it is not currently performed. Objective: In this study, we aimed to determine CMV-IgM positive predictive values (PPV) in different clinical settings. Material and methods: We conducted a retrospective study on positive CMV-IgM in our virology laboratory from 2013 to 2019, in three clinical groups: screening in non-symptomatic pregnant women (group 1), pregnant women with ultrasound (US) abnormalities (group 2) and patients (general population) with clinical signs suggestive of CMV primary infection (group 3). CMV-IgG avidity had been performed in all cases allowing to evaluate PPV of positive CMV-IgM to diagnose CMV primary-infection in each group. Results: Between 2013 and 2019, 6859 serum samples were found positive for CMV-IgM and had been tested for CMV-IgG avidity, with 6560 sera for group 1, 30 for group 2 and 269 for group 3. Overall, low avidity confirming primary infection was observed respectively in 16.4 % for group 1, 36.7 % for group 2, and 35.3 % for group 3. CMV-IgM PPV was significantly lower in group 1 compared to groups 2 (p = 0.01) and 3 (p < 0.001). Discussion: Our observations highlight the major importance of including CMV-IgG avidity in the diagnostic algorithm, whatever the clinical situation (for immunocompetent patients), to confirm or exclude a recent CMV primary infection in case of positive CMV-IgM.
Fichier principal
Vignette du fichier
JCV-D-20-01378R1-1.pdf (2.62 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-03227598 , version 1 (17-05-2021)
inserm-03227598 , version 2 (25-05-2021)

Identifiers

Cite

Claire Périllaud-Dubois, Elise Bouthry, Abir Jadoui, Ay-Ling Leng, Anne-Marie Roque-Afonso, et al.. Positive predictive values of CMV-IgM and importance of CMV-IgG avidity testing in detecting primary infection in three different clinical settings. A French retrospective cohort study. Journal of Clinical Virology, 2020, 132, pp.104641. ⟨10.1016/j.jcv.2020.104641⟩. ⟨inserm-03227598v2⟩
107 View
173 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More