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Relation pharmacocinétique/pharmacodynamique entre la concentration sanguine de tétrahydrocannabinol et l’aptitude à conduire un véhicule chez des consommateurs occasionnels ou chroniques de cannabis

Abstract : Objective The pharmacokinetic/pharmacodynamic (PK/PD) relationship between blood tétrahydrocannabinol (THC) concentrations after smoking and the ability to drive is poorly documented. Methods THC and its metabolites were measured in the blood of chronic users (CC, 1–2 joints/day) and 15 occasional users (CO, 1–2 joints/week) 12 times over 24 h after randomized placebo-controlled smoking containing 10 mg or 30 mg of THC. The effects were evaluated 7 times by a vigilance test (reaction time) and a driving simulator during the same period. Results There is no PK/PD relationship. The blood concentration for THC and 11-OH-THC is maximal at the end of the consumption whereas the effects are strongest about 5 h later. After the same dose consumed, the blood concentration of THC is almost twice as high in CC than in CO. CC always have THC in the blood (>1 ng/mL) after 24 h whereas it is < 0.5 ng/mL in CO after approximately 6 h. The effects on reaction time are greater for CO (+19% at 10 mg and +27% at 30 mg) than for CC (+11% at 10 mg and +19% at 30 mg). This is also the case for the ability to drive where there is no dose effect (+25% driving error for CC vs. +34% in CO). The total effect on driving lasts about 8 h in CC and up to 13 h in CO. Conclusion Cannabis has a deleterious effect on the ability to drive, delayed in time compared to the blood kinetics of THC.
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https://www.hal.inserm.fr/inserm-03223763
Contributor : Christine Dupuis <>
Submitted on : Tuesday, May 11, 2021 - 10:31:46 AM
Last modification on : Thursday, July 8, 2021 - 3:52:17 AM

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J.C. Alvarez, N. Simon, I.A. Larabi, M. Ribot, N. Derridj-Ait-Younes, et al.. Relation pharmacocinétique/pharmacodynamique entre la concentration sanguine de tétrahydrocannabinol et l’aptitude à conduire un véhicule chez des consommateurs occasionnels ou chroniques de cannabis. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2020, 204 (5), pp.477-485. ⟨10.1016/j.banm.2019.11.017⟩. ⟨inserm-03223763⟩

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