Skip to Main content Skip to Navigation
Journal articles

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

Abstract : The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in blood glucose levels during fasting alters the structural organization of this blood-hypothalamus barrier, resulting in the improved access of metabolic substrates to the arcuate nucleus. These changes are mimicked by 2-deoxyglucose-induced glucoprivation and reversed by raising blood glucose levels after fasting. Furthermore, we show that VEGF-A expression in tanycytes modulates these barrier properties. The neutralization of VEGF signaling blocks fasting-induced barrier remodeling and significantly impairs the physiological response to refeeding. These results implicate glucose in the control of blood-hypothalamus exchanges through a VEGF-dependent mechanism and demonstrate a hitherto unappreciated role for tanycytes and the permeable microvessels associated with them in the adaptive metabolic response to fasting.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03204462
Contributor : Vincent Prevot <>
Submitted on : Thursday, April 22, 2021 - 2:18:10 PM
Last modification on : Saturday, April 24, 2021 - 3:19:55 AM

File

Langlet Cell Metab final man.p...
Files produced by the author(s)

Identifiers

Citation

Fanny Langlet, Barry  Levin, Serge Luquet, Massimiliano Mazzone, Andrea Messina, et al.. Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting. Cell Metabolism, Elsevier, 2013, 17 (4), pp.607-617. ⟨10.1016/j.cmet.2013.03.004⟩. ⟨inserm-03204462v2⟩

Share

Metrics

Record views

46

Files downloads

38