Skip to Main content Skip to Navigation
Journal articles

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

Abstract : A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reproduction in mammals by secreting the 'master molecule' gonadotropin-releasing hormone (GnRH). Timely postnatal changes in GnRH expression are essential for puberty and adult fertility. Here we report that a multilayered microRNA-operated switch with built-in feedback governs increased GnRH expression during the infantile-to-juvenile transition and that impairing microRNA synthesis in GnRH neurons leads to hypogonadotropic hypogonadism and infertility in mice. Two essential components of this switch, miR-200 and miR-155, respectively regulate Zeb1, a repressor of Gnrh transcriptional activators and Gnrh itself, and Cebpb, a nitric oxide-mediated repressor of Gnrh that acts both directly and through Zeb1, in GnRH neurons. This alteration in the delicate balance between inductive and repressive signals induces the normal GnRH-fuelled run-up to correct puberty initiation, and interfering with this process disrupts the neuroendocrine control of reproduction.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03204447
Contributor : Vincent Prevot <>
Submitted on : Thursday, April 22, 2021 - 2:11:21 PM
Last modification on : Saturday, April 24, 2021 - 3:19:55 AM

File

Messina NatNeurosci Rev man.pd...
Files produced by the author(s)

Identifiers

Citation

Andrea Messina, Fanny Langlet, Konstantina Chachlaki, Juan Roa, Sowmyalakshmi Rasika, et al.. A microRNA switch regulates the rise in hypothalamic GnRH production before puberty. Nature Neuroscience, Nature Publishing Group, 2016, 19 (6), pp.835-844. ⟨10.1038/nn.4298⟩. ⟨inserm-03204447v2⟩

Share

Metrics

Record views

68

Files downloads

70