Skip to Main content Skip to Navigation
Journal articles

Nutritional and developmental programming effects of insulin

Abstract : The discovery of insulin in 1921 was a major breakthrough in medicine and for therapy in patients with diabetes. The dramatic rise in the prevalence of overweight and obesity has been tightly linked to an increased prevalence of gestational diabetes mellitus (GDM), which poses major health concerns. Babies born to GDM mothers are more likely to develop obesity, type 2 diabetes and cardiovascular disease later in life. Evidence accumulated during the past two decades has revealed that high levels insulin, such as those observed during GDM, can have a widespread effect on the development and function of a variety of organs. This review summarises our current knowledge on the role of insulin in the placenta, cardiovascular system and brain during critical periods of development, as well as how it can contribute to lifelong metabolic regulation. We also discuss possible intervention strategies to ameliorate and hopefully reverse the developmental defects associated with obesity and GDM.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03204429
Contributor : Sebastien Bouret <>
Submitted on : Wednesday, April 21, 2021 - 3:05:56 PM
Last modification on : Friday, April 23, 2021 - 3:16:41 AM

Identifiers

Collections

Citation

Laura Dearden, Sebastien Bouret, Susan Ozanne. Nutritional and developmental programming effects of insulin. Journal of Neuroendocrinology, Wiley, 2021, 33 (4), pp.e12933. ⟨10.1111/jne.12933⟩. ⟨inserm-03204429⟩

Share

Metrics

Record views

17