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Of mice and men: fuzzy tandem repeats and divergent p53 transcriptional repertoires

Abstract : The clinical importance of tumor suppressor p53 makes it one of the most studied transcription factors. A comparison of mammalian p53 transcriptional repertoires may help identify fundamental principles in genome evolution and better understand cancer processes. Here we summarize mechanisms underlying the divergence of mammalian p53 transcriptional repertoires, with an emphasis on the rapid evolution of fuzzy tandem repeats containing p53 response elements.
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https://www.hal.inserm.fr/inserm-03198945
Contributor : Franck Toledo <>
Submitted on : Thursday, April 15, 2021 - 11:53:02 AM
Last modification on : Friday, April 16, 2021 - 3:25:58 AM

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Aurélie Morin, Boris Bardot, Iva Simeonova, Vincent Lejour, Rachida Bouarich-Bourimi, et al.. Of mice and men: fuzzy tandem repeats and divergent p53 transcriptional repertoires. Transcription, Taylor & Francis, 2014, 4 (2), pp.67-71. ⟨10.4161/trns.23772⟩. ⟨inserm-03198945⟩

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