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Mechanisms generating cancer genome complexity: a look back at the interphase breakage model

Abstract : Understanding the mechanims responsible for cancer genome complexity has been an important goal for many decades. Umbreit et al. recently combined live cell imaging and single cell genome sequencing to analyze the cascade of genome rearrangements following the formation of a chromosome bridge in human cells (1). Their results suggest that this bridge leads to an initial breakage-fusion-bridge (BFB) cycle, followed by additional BFB cycles interwoven with episodes of micronucleation and chromothripsis, to generate complex genome rearrangements (1). This conclusion is strikingly consistent with the previously proposed “interphase breakage model” (2).
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https://www.hal.inserm.fr/inserm-03198389
Contributor : Franck Toledo <>
Submitted on : Wednesday, April 14, 2021 - 6:24:53 PM
Last modification on : Thursday, July 8, 2021 - 3:46:39 AM
Long-term archiving on: : Thursday, July 15, 2021 - 7:13:55 PM

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Franck Toledo, Michelle Debatisse. Mechanisms generating cancer genome complexity: a look back at the interphase breakage model. 2020. ⟨inserm-03198389⟩

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