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Antidepressant‐like effect of low dose of scopolamine in the H/Rouen genetic mouse model of depression

Abstract : Rodent models of depression are useful for the investigation of cellular and neuronal mechanisms of antidepressant drugs and for the discovery of potential new targets. In this study, we examined the antidepressant-like effect of scopolamine, a non-selective muscarinic antagonist, in a genetic mouse model of depression obtained through a selective breeding strategy and called H/Rouen. In this model, we observed that scopolamine was active both in males and females at a lower dose (0.03 mg/kg) in the tail suspension test, 30 min following its administration, than observed in CD-1 mice. In addition, we showed this antidepressant-like effect was partly inhibited by an injection of 10 mg/kg of the AMPA receptor antagonist NBQX in both males and females, suggesting the anti-depressant like effect of scopolamine was mainly driven by AMPA receptors in the H/Rouen mouse line. Altogether, our results showed the high sensitivity of the H/Rouen mouse model of depression to study the antidepressant-like effects of pharmacological compounds.
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https://www.hal.inserm.fr/inserm-03198220
Contributor : Stéphane Jamain <>
Submitted on : Wednesday, April 14, 2021 - 4:22:20 PM
Last modification on : Thursday, April 15, 2021 - 3:26:39 AM

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Malika El Yacoubi, Jean-Marie Vaugeois, Stéphane Jamain. Antidepressant‐like effect of low dose of scopolamine in the H/Rouen genetic mouse model of depression. Fundamental and Clinical Pharmacology, Wiley, 2020, Online ahead of print. ⟨10.1111/fcp.12639⟩. ⟨inserm-03198220⟩

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