Skip to Main content Skip to Navigation
Journal articles

Kaposi sarcoma among people living with HIV in the French DAT ’ AIDS cohort between 2010 and 2015

I. Poizot‐martin 1 V. Obry‐roguet 2 C. Duvivier 3, 4, 5, 6 C. Lions 2 T. Huleux 7 C. Jacomet 8 T. Ferry 9 A. Cheret 10, 11 C. Allavena 12 F. Bani‐sadr 13 R. Palich 14, 15 A. Cabié 16, 17, 18 A. Fresard 19 P. Pugliese 20 P. Delobel 21 I. Lamaury 22 L. Hustache‐mathieu 23 S. Brégigeon 2 A. Makinson 24 D. Rey 25
Abstract : Background: Although antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV-infected people. Objective: To describe all KS cases observed between 2010 and 2015 in a country with high ART coverage. Methods: Retrospective study using longitudinal data from 44 642 patients in the French Dat'AIDS multicenter cohort. Patients' characteristics were described at KS diagnosis according to ART exposure and to HIV-plasma viral load (HIV-pVL) (≤50 or >50) copies/mL. Results: Among the 209 KS cases diagnosed during the study period, 33.2% occurred in ART naïve patients, 17.3% in ART-experienced patients and 49.5% in patients on ART, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had HIV-pVL ≤50 cp/mL, and 16 (66%) were treated with a boosted-PI-based regimen. The distribution of KS localization did not differ by ART status nor by year of diagnosis. Limitations: Data on human herpesvirus 8, treatment modalities for KS and response rate were not collected. Conclusion: Half of KS cases observed in the study period occurred in patients not on ART, reflecting the persistence of late HIV diagnosis. Factors associated with KS in patients on ART with HIV-pVL ≤50 cp/mL remain to be explored.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03198175
Contributor : Christine Dupuis <>
Submitted on : Wednesday, April 14, 2021 - 3:57:56 PM
Last modification on : Wednesday, June 2, 2021 - 4:26:13 PM

File

jdv.16204.pdf
Publication funded by an institution

Identifiers

Citation

I. Poizot‐martin, V. Obry‐roguet, C. Duvivier, C. Lions, T. Huleux, et al.. Kaposi sarcoma among people living with HIV in the French DAT ’ AIDS cohort between 2010 and 2015. Journal of the European Academy of Dermatology and Venereology, Wiley, 2020, 34 (5), pp.1065 - 1073. ⟨10.1111/jdv.16204⟩. ⟨inserm-03198175⟩

Share

Metrics

Record views

96

Files downloads

91