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A New Rise of Non-Human Primate Models of Synucleinopathies

Abstract : Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopathy. Non-human primate (NHP) models are of interest in neurodegenerative diseases as they constitute the highest relevant preclinical model in translational research. They also contribute to bringing new insights into synucleinopathy’s pathogenicity and help in the quest and validation of therapeutical strategies. Here, we reviewed the different NHP models that have recapitulated key characteristics of synucleinopathy, and we aimed to highlight the contribution of NHP in mechanistic and translational approaches for synucleinopathies.
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https://www.hal.inserm.fr/inserm-03183606
Contributor : Benjamin Dehay <>
Submitted on : Sunday, March 28, 2021 - 10:47:34 AM
Last modification on : Tuesday, March 30, 2021 - 3:35:06 AM
Long-term archiving on: : Tuesday, June 29, 2021 - 6:05:20 PM

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Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay. A New Rise of Non-Human Primate Models of Synucleinopathies. Biomedicines, MDPI, 2021, 9 (3), pp.272. ⟨10.3390/biomedicines9030272⟩. ⟨inserm-03183606⟩

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