Skip to Main content Skip to Navigation
Journal articles

A New Rise of Non-Human Primate Models of Synucleinopathies

Abstract : Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopathy. Non-human primate (NHP) models are of interest in neurodegenerative diseases as they constitute the highest relevant preclinical model in translational research. They also contribute to bringing new insights into synucleinopathy’s pathogenicity and help in the quest and validation of therapeutical strategies. Here, we reviewed the different NHP models that have recapitulated key characteristics of synucleinopathy, and we aimed to highlight the contribution of NHP in mechanistic and translational approaches for synucleinopathies.
Document type :
Journal articles
Complete list of metadata
Contributor : Benjamin Dehay Connect in order to contact the contributor
Submitted on : Sunday, March 28, 2021 - 10:47:34 AM
Last modification on : Friday, April 1, 2022 - 3:44:47 AM
Long-term archiving on: : Tuesday, June 29, 2021 - 6:05:20 PM


Publisher files allowed on an open archive




Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay. A New Rise of Non-Human Primate Models of Synucleinopathies. Biomedicines, MDPI, 2021, 9 (3), pp.272. ⟨10.3390/biomedicines9030272⟩. ⟨inserm-03183606⟩



Record views


Files downloads