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PPARs in liver physiology

Abstract : Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and transcriptional modulators with crucial functions in hepatic and whole-body energy homeostasis. Besides their well-documented roles in lipid and glucose metabolism, emerging evidence also implicate PPARs in the control of other processes such as inflammatory responses. Recent technological advances, such as single-cell RNA sequencing, have allowed to unravel an unexpected complexity in the regulation of PPAR expression, activity and downstream signaling. Here we provide an overview of the latest advances in the study of PPARs in liver physiology, with a specific focus on formerly neglected aspects of PPAR regulation, such as tissular zonation, cellular heterogeneity, circadian rhythms, sexual dimorphism and species-specific features.
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https://www.hal.inserm.fr/inserm-03176517
Contributor : Marie-Hélène Derudas <>
Submitted on : Monday, March 22, 2021 - 2:25:07 PM
Last modification on : Monday, March 29, 2021 - 2:43:07 PM

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Alexandre Berthier, Manuel Johanns, Francesco Zummo, Philippe Lefebvre, Bart Staels. PPARs in liver physiology. Biochimica et Biophysica Acta - Molecular Basis of Disease, Elsevier, 2021, 1867 (5), pp.166097. ⟨10.1016/j.bbadis.2021.166097⟩. ⟨inserm-03176517⟩

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