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Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations

Sietske A.M. Sikkes 1, 2 Yi Tang 3 Roos Jutten 1, 2 Linda M.P. Wesselman 1, 2 Lyn Turkstra 4 Henry Brodaty 5, 6 Linda Clare 7 Erin Cassidy‐eagle 8 Kay Cox 9 Gaël Chételat 10 Sophie Dautricourt 10 Klodian Dhana 11 Hiroko Dodge 12, 13 Rose‐marie Dröes 1 Benjamin Hampstead 13 Thomas Holland 11 Amit Lampit 14 Kate Laver 15 Antoine Lutz 16 Nicola Lautenschlager 14, 17 Susan Mccurry 18 Franka Meiland 1 Martha Clare Morris 11 Kimberly Mueller 19 Ruth Peters 6, 20 Gemma Ridel 21 Aimee Spector 22 Jenny Steen 23, 24 Jeanette Tamplin 14 Zara Thompson 14 Alex Bahar-Fuchs 14, 25
Abstract : Introduction: Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results. Methods: In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System. Results: Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols. Discussion: We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.
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https://www.hal.inserm.fr/inserm-03174443
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Submitted on : Friday, March 19, 2021 - 11:06:55 AM
Last modification on : Tuesday, October 19, 2021 - 11:35:06 PM

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Sietske A.M. Sikkes, Yi Tang, Roos Jutten, Linda M.P. Wesselman, Lyn Turkstra, et al.. Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2021, 17 (2), pp.255-270. ⟨10.1002/alz.12188⟩. ⟨inserm-03174443⟩

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