Skip to Main content Skip to Navigation
Journal articles

How Degeneration of Cells Surrounding Motoneurons Contributes to Amyotrophic Lateral Sclerosis

Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the progressive degeneration of upper and lower motoneurons. Despite motoneuron death being recognized as the cardinal event of the disease, the loss of glial cells and interneurons in the brain and spinal cord accompanies and even precedes motoneuron elimination. In this review, we provide striking evidence that the degeneration of astrocytes and oligodendrocytes, in addition to inhibitory and modulatory interneurons, disrupt the functionally coherent environment of motoneurons. We discuss the extent to which the degeneration of glial cells and interneurons also contributes to the decline of the motor system. This pathogenic cellular network therefore represents a novel strategic field of therapeutic investigation.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03169112
Contributor : Cédric Raoul <>
Submitted on : Monday, March 15, 2021 - 10:16:45 AM
Last modification on : Tuesday, March 16, 2021 - 3:23:46 AM
Long-term archiving on: : Wednesday, June 16, 2021 - 6:23:41 PM

File

Cells 2020.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Roxane Crabé, Franck Aimond, Philippe Gosset, Frédérique Scamps, Cédric Raoul. How Degeneration of Cells Surrounding Motoneurons Contributes to Amyotrophic Lateral Sclerosis. Cells, MDPI, 2020, 9 (12), pp.2550. ⟨10.3390/cells9122550⟩. ⟨inserm-03169112⟩

Share

Metrics

Record views

28

Files downloads

30