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Journal articles
How Degeneration of Cells Surrounding Motoneurons Contributes to Amyotrophic Lateral Sclerosis
Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the progressive degeneration of upper and lower motoneurons. Despite motoneuron death being recognized as the cardinal event of the disease, the loss of glial cells and interneurons in the brain and spinal cord accompanies and even precedes motoneuron elimination. In this review, we provide striking evidence that the degeneration of astrocytes and oligodendrocytes, in addition to inhibitory and modulatory interneurons, disrupt the functionally coherent environment of motoneurons. We discuss the extent to which the degeneration of glial cells and interneurons also contributes to the decline of the motor system. This pathogenic cellular network therefore represents a novel strategic field of therapeutic investigation.
https://www.hal.inserm.fr/inserm-03169112
Contributor : Cédric Raoul Connect in order to contact the contributor
Submitted on : Monday, March 15, 2021 - 10:16:45 AM
Last modification on : Wednesday, October 27, 2021 - 9:47:18 AM
Long-term archiving on: : Wednesday, June 16, 2021 - 6:23:41 PM
Contributor : Cédric Raoul Connect in order to contact the contributor
Submitted on : Monday, March 15, 2021 - 10:16:45 AM
Last modification on : Wednesday, October 27, 2021 - 9:47:18 AM
Long-term archiving on: : Wednesday, June 16, 2021 - 6:23:41 PM
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Cells 2020.pdf
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