Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III
Christer Janson
(1, 2)
,
Simone Accordini
(3)
,
Lucia Cazzoletti
(3)
,
Isa Cerveri
(4)
,
Sebastien Chanoine
(5)
,
Angelo Corsico
(4)
,
Diogenes Seraphim Ferreira
(6, 7)
,
Judith Garcia-Aymerich
(8, 9, 10)
,
David Gislason
(11)
,
Rune Nielsen
(12, 13)
,
Ane Johannessen
(13)
,
Rain Jogi
(14)
,
Andrei Malinovschi
(1)
,
Jesús Martinez-Moratalla Rovira
(15, 16)
,
Alessandro Marcon
(3)
,
Isabelle Pin
(5, 17)
,
Jennifer Quint
(2)
,
Valerie Siroux
(18, 5)
,
Enrique Almar
(16, 19)
,
Valeria Bellisario
(20)
,
Karl Franklin
(21)
,
José Gullón
(22)
,
Mathias Holm
(23)
,
Joachim Heinrich
(24, 25, 26)
,
Dennis Nowak
(24, 27)
,
José Luis Sánchez-Ramos
(28)
,
Joost Weyler
(29)
,
Déborah Jarvis
(2)
1
Uppsala University
2 NHLI - National Heart and Lung Institute [London]
3 UNIVR - Università degli studi di Verona = University of Verona
4 UNIPV - Università degli Studi di Pavia = University of Pavia
5 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
6 Monash University [Melbourne]
7 UFPR - Universidade Federal do Parana [Curitiba]
8 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
9 UPF - Universitat Pompeu Fabra [Barcelona]
10 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
11 Landspitali National University Hospital of Iceland
12 Haukeland University Hospital
13 UiB - University of Bergen
14 Tartu University Hospital [Tartu, Estonia]
15 Complejo Hospitalario Universitario de Albacete
16 UCLM - Universidad de Castilla-La Mancha = University of Castilla-La Mancha
17 Service de chirurgie pédiatrique [CHU Grenoble]
18 UGA - Université Grenoble Alpes
19 Service of the Health Delegation of Albacete [Albacete, Spain]
20 UNITO - Università degli studi di Torino = University of Turin
21 Umeå University
22 UNSA - Universidad Nacional de San Agustín
23 GU - Göteborgs Universitet = University of Gothenburg
24 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
25 Helmholtz Zentrum München = German Research Center for Environmental Health
26 Melbourne School of Population and Global Health [Melbourne]
27 German Center for Lung Research - DZL [Munich, Germany]
28 Universidad de Huelva
29 UA - University of Antwerp
2 NHLI - National Heart and Lung Institute [London]
3 UNIVR - Università degli studi di Verona = University of Verona
4 UNIPV - Università degli Studi di Pavia = University of Pavia
5 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
6 Monash University [Melbourne]
7 UFPR - Universidade Federal do Parana [Curitiba]
8 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
9 UPF - Universitat Pompeu Fabra [Barcelona]
10 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
11 Landspitali National University Hospital of Iceland
12 Haukeland University Hospital
13 UiB - University of Bergen
14 Tartu University Hospital [Tartu, Estonia]
15 Complejo Hospitalario Universitario de Albacete
16 UCLM - Universidad de Castilla-La Mancha = University of Castilla-La Mancha
17 Service de chirurgie pédiatrique [CHU Grenoble]
18 UGA - Université Grenoble Alpes
19 Service of the Health Delegation of Albacete [Albacete, Spain]
20 UNITO - Università degli studi di Torino = University of Turin
21 Umeå University
22 UNSA - Universidad Nacional de San Agustín
23 GU - Göteborgs Universitet = University of Gothenburg
24 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
25 Helmholtz Zentrum München = German Research Center for Environmental Health
26 Melbourne School of Population and Global Health [Melbourne]
27 German Center for Lung Research - DZL [Munich, Germany]
28 Universidad de Huelva
29 UA - University of Antwerp
Christer Janson
- Fonction : Auteur
- PersonId : 760517
- ORCID : 0000-0001-5093-6980
Isa Cerveri
- Fonction : Auteur
- PersonId : 760516
- ORCID : 0000-0003-0337-043X
Diogenes Seraphim Ferreira
- Fonction : Auteur
- PersonId : 806113
- ORCID : 0000-0002-6086-835X
Judith Garcia-Aymerich
- Fonction : Auteur
- PersonId : 766819
- ORCID : 0000-0002-7097-4586
- IdRef : 184015847
Ane Johannessen
- Fonction : Auteur
- PersonId : 791100
- ORCID : 0000-0003-3269-8354
Isabelle Pin
- Fonction : Auteur
- PersonId : 756749
- ORCID : 0000-0002-7529-6999
Déborah Jarvis
- Fonction : Auteur
- PersonId : 15167
- IdHAL : deborah-lurienne
- ORCID : 0000-0003-2185-7321
Résumé
Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries. The use of ICSs increased from 1.7% to 5.9% in the general population and the regular use of ICSs increased from 19% to 34% among persistent asthmatic subjects. The proportion of asthmatic subjects reporting asthma attacks in the last 12 months decreased, while the proportion that had seen a doctor in the last 12 months remained unchanged (42%). Subjects with asthma who had experienced attacks or had seen a doctor were more likely to use ICSs on a regular basis. Although ICS use has increased, only one-third of subjects with persistent asthma take ICSs on a regular basis. Less than half had seen a doctor during the last year. This indicates that underuse of ICSs and lack of regular healthcare contacts remains a problem in the management of asthma.