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Le sommeil dans les cancers non-cérébraux : revue de la littérature, mécanismes potentiels et perspectives pour mieux comprendre les troubles cognitifs associés

Abstract : Breast cancer patients have frequent complaints of sleep disturbances. Sleep plays a major role in cognitive functioning, especially in executive functions, such as planning or flexibility, and also in memory consolidation. These cognitive functions are among the most frequently impaired in breast cancer. However, the influence of sleep on cognitive performance in patients treated for breast cancer has been little investigated. In addition, the physio-pathological mechanisms associated with sleep disturbances in breast cancer patients are not clear for now. The objective of this non-exhaustive review is to describe sleep alterations encountered in breast cancer, their potential mechanisms and to link these alterations with cognitive difficulties of patients. The studies conducted until now revealed the existence of a sleep complaint, with mainly insomnia symptoms, in breast cancer patients. These results are in accordance with those of studies using actigraphy after chemotherapy. Polysomnography (PSG) studies also suggest alterations in sleep architecture, but these studies are scarce and suffer from several limitations. Sleep alterations have mainly been studied in the context of chemotherapy. However, sleep alterations are little studied in case of other treatments, such as hormonal therapy, or even in the absence of treatment. Recent studies have highlighted the potential role of sleep–wake cycle alterations and sleep apnea in breast cancer occurrence and survival; however, this association still needs to be more deeply evaluated. Finally, the links between objective sleep alterations and cognition are still little explored. A better understanding of sleep disorders in breast cancer will allow adapting the treatment in order to improve patients’ quality of life.
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https://www.hal.inserm.fr/inserm-03150709
Contributor : Joy Perrier <>
Submitted on : Wednesday, February 24, 2021 - 8:34:58 AM
Last modification on : Thursday, February 25, 2021 - 5:18:01 PM

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Joy Perrier, Mylène Duivon, Géraldine Rauchs, Bénédicte Giffard. Le sommeil dans les cancers non-cérébraux : revue de la littérature, mécanismes potentiels et perspectives pour mieux comprendre les troubles cognitifs associés. Médecine du sommeil, Elsevier Masson, 2021, ⟨10.1016/j.msom.2020.12.002⟩. ⟨inserm-03150709⟩

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