Skip to Main content Skip to Navigation
Journal articles

The Bradyzoite: A Key Developmental Stage for the Persistence and Pathogenesis of Toxoplasmosis

Abstract : Toxoplasma gondii is a ubiquitous parasitic protist found in a wide variety of hosts, including a large proportion of the human population. Beyond an acute phase which is generally self-limited in immunocompetent individuals, the ability of the parasite to persist as a dormant stage, called bradyzoite, is an important aspect of toxoplasmosis. Not only is this stage not eliminated by current treatments, but it can also reactivate in immunocompromised hosts, leading to a potentially fatal outcome. Yet, despite its critical role in the pathology, the bradyzoite stage is relatively understudied. One main explanation is that it is a considerably challenging model, which essentially has to be derived from in vivo sources. However, recent progress on genetic manipulation and in vitro differentiation models now offers interesting perspectives for tackling key biological questions related to this particularly important developmental stage.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03143289
Contributor : Sébastien Besteiro <>
Submitted on : Tuesday, February 16, 2021 - 5:18:48 PM
Last modification on : Tuesday, February 23, 2021 - 8:23:05 AM
Long-term archiving on: : Monday, May 17, 2021 - 9:08:33 PM

File

pathogens-09-00234.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Aude Cerutti, Nicolas Blanchard, Sébastien Besteiro. The Bradyzoite: A Key Developmental Stage for the Persistence and Pathogenesis of Toxoplasmosis. Pathogens, MDPI, 2020, 9 (3), pp.234. ⟨10.3390/pathogens9030234⟩. ⟨inserm-03143289⟩

Share

Metrics

Record views

79

Files downloads

53