Skip to Main content Skip to Navigation
Journal articles

ER-PM Contact Sites – SNARING Actors in Emerging Functions

Abstract : The compartmentalisation achieved by confining cytoplasm into membrane-enclosed organelles in eukaryotic cells is essential for maintaining vital functions including ATP production, synthetic and degradative pathways. While intracellular organelles are highly specialised in these functions, the restricting membranes also impede exchange of molecules responsible for the synchronised and responsive cellular activities. The initial identification of contact sites between the ER and plasma membrane (PM) provided a potential candidate structure for communication between organelles without mixing by fusion. Over the past decades, research has revealed a far broader picture of the events. Membrane contact sites (MCSs) have been recognized as increasingly important actors in cell differentiation, plasticity and maintenance, and, upon dysfunction, responsible for pathological conditions such as cancer and neurodegenerative diseases. Present in multiple organelles and cell types, MCSs promote transport of lipids and Ca2+ homoeostasis, with a range of associated protein families. Interestingly, each MCS displays a unique molecular signature, adapted to organelle functions. This review will explore the literature describing the molecular components and interactions taking place at ER-PM contact sites, their functions, and implications in eukaryotic cells, particularly neurons, with emphasis on lipid transfer proteins and emerging function of SNAREs.
Complete list of metadata

https://www.hal.inserm.fr/inserm-03143157
Contributor : Clara Martinez Rico <>
Submitted on : Tuesday, February 16, 2021 - 3:58:13 PM
Last modification on : Wednesday, June 2, 2021 - 4:26:11 PM
Long-term archiving on: : Monday, May 17, 2021 - 8:34:01 PM

File

Hewlett et al Front Cell Dev B...
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Bailey Hewlett, Neha Singh, Christian Vannier, Thierry Galli. ER-PM Contact Sites – SNARING Actors in Emerging Functions. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, ⟨10.3389/fcell.2021.635518⟩. ⟨inserm-03143157⟩

Share

Metrics

Record views

92

Files downloads

115