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Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration

Abstract : Polysaccharides have received a lot of attention in biomedical research for their high potential as scaffolds owing to their unique biological properties. Fibrillar scaffolds made of chitosan demonstrated high promise in tissue engineering, especially for skin. As far as bone regeneration is concerned, curdlan (1,3‐β‐glucan) is particularly interesting as it enhances bone growth by helping mesenchymal stem cell adhesion, by favoring their differentiation into osteoblasts and by limiting the osteoclastic activity. Therefore, we aim to combine both chitosan and curdlan polysaccharides in a new scaffold for bone regeneration. For that purpose, curdlan was electrospun as a blend with chitosan into a fibrillar scaffold. We show that this novel scaffold is biodegradable (8% at two weeks), exhibits a good swelling behavior (350%) and is non‐cytotoxic in vitro. In addition, the benefit of incorporating curdlan in the scaffold was demonstrated in a scratch assay that evidences the ability of curdlan to express its immunomodulatory properties by enhancing cell migration. Thus, these innovative electrospun curdlan–chitosan scaffolds show great potential for bone tissue engineering.
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https://www.hal.inserm.fr/inserm-03137953
Contributor : Valérie Pecqueret <>
Submitted on : Wednesday, February 10, 2021 - 6:18:37 PM
Last modification on : Monday, May 10, 2021 - 11:20:03 AM
Long-term archiving on: : Tuesday, May 11, 2021 - 9:06:56 PM

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Clément Toullec, Jean Le Bideau, Valerie Geoffroy, Boris Halgand, Nela Buchtova, et al.. Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration. Polymers, MDPI, 2021, 13, pp.526. ⟨10.3390/polym13040526⟩. ⟨inserm-03137953⟩

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