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Influence of HLA‐C environment on the spontaneous clearance of hepatitis C in European HIV–HCV co‐infected individuals

Abstract : Natural killer (NK) cell functions are regulated by diverse inhibitory and activating receptors, including killer cell immunoglobulin-like receptors (KIR), which interact with human leukocyte antigen (HLA) class I molecules. Some KIR/HLA genetic combinations were reported associated with spontaneous clearance (SC) of hepatitis C virus (HCV) but with discordant results, possibly reflecting KIR and/or HLA gene polymorphism according to populations. KIR/HLA genetic combinations associated with both an exhaustive NK and T cell repertoire were investigated in a cohort of HIV-HCV co-infected individuals with either SC (n = 68) or chronic infection (CI, n = 163) compared to uninfected blood donors [controls (Ctrl), n = 100]. Multivariate analysis showed that the HLA C2C2 environment was associated with SC only in European HIV-HCV co-infected individuals [odds ratio (OR) = 4•30, 95% confidence interval = 1•57-12•25, P = 0•005]. KIR2D + NK cell repertoire and potential of degranulation of KIR2DL1/S1 + NK cells were similar in the SC European cohort compared to uninfected individuals. In contrast, decreased frequencies of KIR2DS1 + and KIR2DL2 + NK cells were detected in the CI group of Europeans compared to SC and a decreased frequency of KIR2DL1/S1 + NK cells compared to controls. Regarding T cells, higher frequencies of DNAX accessory molecule-1 (DNAM-1) + and CD57 + T cells were observed in SC in comparison to controls. Interestingly, SC subjects emphasized increased frequencies of KIR2DL2/L3/S2 + T cells compared to CI subjects. Our study underlines that the C2 environment may activate efficient KIR2DL1 + NK cells in a viral context and maintain a KIR2DL2/L3/S2 + mature T cell response in the absence of KIR2DL2 engagement with its cognate ligands in SC group of HCV-HIV co-infected European patients.
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Contributor : Elizabeth Bernardo <>
Submitted on : Wednesday, February 10, 2021 - 9:49:33 AM
Last modification on : Friday, March 5, 2021 - 2:44:02 PM


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N Legrand, G David, A Rodallec, A Gaultier, D Salmon, et al.. Influence of HLA‐C environment on the spontaneous clearance of hepatitis C in European HIV–HCV co‐infected individuals. Clinical and Experimental Immunology, Wiley, 2021, Online ahead of print. ⟨10.1111/cei.13562⟩. ⟨inserm-03136993⟩



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