Skip to Main content Skip to Navigation
Journal articles

Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress

Abstract : Glioblastomas (GBM) are the most common primary brain tumor with a median survival of 15 months. A population of cells with stem cell properties (glioblastoma stem cells, GSCs) drives the initiation and progression of GBM and is localized in specialized microenvironments which support their behavior. GBM are characterized as extremely resistant to therapy, resulting in tumor recurrence. Reactive oxygen species (ROS) control the cellular stability by influencing different signaling pathways. Normally, redox systems prevent cell oxidative damage; however, in gliomagenesis, the cellular redoxmechanisms are highly impaired. Herein we review the dual nature of the redox status in drug resistance. ROS generation in tumor cells affects the cell cycle and is involved in tumor progression and drug resistance in GBM. However, excess ROS production has been found to induce cell death programs such as apoptosis and autophagy. Since GBM cells have a highmetabolic rate and produce high levels of ROS,metabolic adaptation in these cells plays an essential role in resistance to oxidative stress-induced cell death. Finally, the microenvironment with the stromal components participates in the enhancement of the oxidative stress to promote tumor progression and drug resistance.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-03136960
Contributor : Elizabeth Bernardo <>
Submitted on : Wednesday, February 10, 2021 - 9:26:33 AM
Last modification on : Thursday, February 11, 2021 - 3:19:12 AM

File

Publi2021Eq9.pdf
Publisher files allowed on an open archive

Identifiers

  • HAL Id : inserm-03136960, version 1

Collections

Citation

Christophe Olivier, Lisa Oliver, Lisenn Lalier, François Vallette. Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress. Frontiers in Molecular Neuroscience, Frontiers Media, 2021. ⟨inserm-03136960⟩

Share

Metrics

Record views

33

Files downloads

27