Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis - Archive ouverte HAL Access content directly
Journal Articles Molecular metabolism Year : 2021

Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis

(1) , (2, 3) , (1) , (4) , (5) , (4) , (1) , (1) , (1) , (1) , (6) , (6) , (1) , (2, 3) , (5) , (4, 7) , (6) , (2, 3) , (1)
1
2
3
4
5
6
7
Hanna Diounou
  • Function : Author
Jocelyne Leclerc
  • Function : Author
Sandra Guilmeau
  • Function : Author
Camille Huet
  • Function : Author
Wafa Charifi
  • Function : Author
Marc Foretz
Benoit Viollet

Abstract

The intestinal epithelial barrier (IEB) restricts the passage from the lumen through the paracellular space of potentially harmful substances and microbes, and rupture of its integrity is associated with a variety of gastrointestinal disorders and extra-digestive diseases. Increased IEB permeability has been linked to disruption of metabolic homeostasis leading to obesity and type 2 diabetes. Interestingly, recent studies have uncovered compelling evidence that the AMP-activated protein kinase (AMPK) signaling pathway plays important role in the maintenance of epithelial cell barrier function. However, our understanding of the function of intestinal AMPK in the regulation of IEB and glucose homeostasis remains sparse.
Fichier principal
Vignette du fichier
MS_Olivier_et_al_+FigsHalInserm (1).pdf (4.84 Mo) Télécharger le fichier
Vignette du fichier
Supplemental Figs_MS Olivier.pdf (2.31 Mo) Télécharger le fichier

Dates and versions

inserm-03135283 , version 1 (08-02-2021)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

Séverine Olivier, Camille Pochard, Hanna Diounou, Vanessa Castillo, Jordane Divoux, et al.. Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis. Molecular metabolism, 2021, pp.101183. ⟨10.1016/j.molmet.2021.101183⟩. ⟨inserm-03135283⟩
68 View
46 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More