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Journal articles
Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis
Séverine Olivier
1
Camille Pochard
2, 3
Hanna Diounou
1
Vanessa Castillo
4
Jordane Divoux
5
Joshua Alcantara
4
Jocelyne Leclerc
1
Sandra Guilmeau
1
Camille Huet
1
Wafa Charifi
1
Thibault Varin
6
Noëmie Daniel
6
Marc Foretz
1
Michel Neunlist
2, 3
Benoit Salomon
5
Pradipta Ghosh
4, 7
André Marette
6
Malvyne Rolli-Derkinderen
2, 3
Benoit Viollet
1
Séverine Olivier 1
Author
Camille Pochard 2, 3
Author
Hanna Diounou 1
Author
Vanessa Castillo 4
Author
Jordane Divoux 5
Author
Joshua Alcantara 4
Author
Jocelyne Leclerc 1
Author
Sandra Guilmeau 1
Author
Marc Foretz 1
Author IdHAL : marc-foretz ResearcherId : http://www.researcherid.com/rid/O-7334-2017 ORCID : https://orcid.org/0000-0001-7017-9032
Michel Neunlist 2, 3
Author
Benoit Salomon 5
Author
Pradipta Ghosh 4, 7
Author
André Marette 6
Author
Malvyne Rolli-Derkinderen 2, 3
Author
Benoit Viollet 1
Author IdHAL : benoit-viollet ResearcherId : http://www.researcherid.com/rid/O-6927-2017 ORCID : https://orcid.org/0000-0002-0121-0224
1
IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1016 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8104 (France)
- UP - Université de Paris : UM 3 (85 boulevard Saint-Germain 75006 Paris - France)
2
TENS - The Enteric Nervous System in gut and brain disorders [U1235] (Faculté de Médecine,
1 rue Gaston Veil,
44035 Nantes - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : 1235 (101, rue de Tolbiac, 75013 Paris - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
3
IMAD - Institut des maladies de l'appareil digestif [Nantes] (France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
4
CMM - Department of Cellular and Molecular Medicine (University of California, San Diego Dept. of Cellular and Molecular Medicine 9500 Gilman Dr. MC 0651 La Jolla, CA 92093-0651 - United States)
- UC San Diego - University of California [San Diego] (9500 Gilman Dr., La Jolla, CA 92093 USA - United States)
- University of California (United States)
5
CIMI - Centre d'Immunologie et de Maladies Infectieuses (91 Boulevard de l'hôpital 75013 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1135 (101, rue de Tolbiac, 75013 Paris - France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : ERL8255 (France)
6
Quebec Heart and Lung Institute (- - Canada)
- ULaval - Université Laval [Québec] (2325, rue de l'Université Québec G1V 0A6 - Canada)
7
Department of Medicine [San Diego] (9500 Gilman Drive
La Jolla San Diego CA 92093 USA - United States)
- UC San Diego - University of California [San Diego] (9500 Gilman Dr., La Jolla, CA 92093 USA - United States)
- University of California (United States)
Abstract : The intestinal epithelial barrier (IEB) restricts the passage from the lumen through the paracellular space of potentially harmful substances and microbes, and rupture of its integrity is associated with a variety of gastrointestinal disorders and extra-digestive diseases. Increased IEB permeability has been linked to disruption of metabolic homeostasis leading to obesity and type 2 diabetes. Interestingly, recent studies have uncovered compelling evidence that the AMP-activated protein kinase (AMPK) signaling pathway plays important role in the maintenance of epithelial cell barrier function. However, our understanding of the function of intestinal AMPK in the regulation of IEB and glucose homeostasis remains sparse.
Document type :
Journal articles
Complete list of metadata
https://www.hal.inserm.fr/inserm-03135283
Contributor : Benoit Viollet <>
Submitted on : Monday, February 8, 2021 - 7:14:08 PM
Last modification on : Wednesday, June 2, 2021 - 4:26:10 PM
Long-term archiving on: : Sunday, May 9, 2021 - 8:47:07 PM
Contributor : Benoit Viollet <>
Submitted on : Monday, February 8, 2021 - 7:14:08 PM
Last modification on : Wednesday, June 2, 2021 - 4:26:10 PM
Long-term archiving on: : Sunday, May 9, 2021 - 8:47:07 PM
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To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-08-03Please log in to resquest access to the document
- Supplemental Figs_MS Olivier.pdf Embargoed until : 2021-08-03
Identifiers
- HAL Id : inserm-03135283, version 1
- DOI : 10.1016/j.molmet.2021.101183
- PUBMED : 33548500
Collections
INSERM | UNIV-NANTES | CNRS | CIMI | UP-SANTE | SORBONNE-UNIVERSITE | SU-MEDECINE | UNIV-PARIS | SU-TI
Citation
Séverine Olivier, Camille Pochard, Hanna Diounou, Vanessa Castillo, Jordane Divoux, et al.. Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis. Molecular metabolism, Elsevier, 2021, pp.101183. ⟨10.1016/j.molmet.2021.101183⟩. ⟨inserm-03135283⟩
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