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Commentary on Rodrigues et al : Towards ecosystem integration for a better understanding of B-cell lymphomas aggressiveness

David Chiron 1
1 CRCINA-ÉQUIPE 10 - Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Commentary on Rodrigues et al Towards ecosystem integration for a better understanding of B-cell lymphomas aggressiveness In this issue of BJH, Rodrigues et al. investigate how tumor-infiltrating immune cells correlated with the clinical outcome of Mantle Cell Lymphoma (MCL), a rare but often aggressive subtype of Non-Hodgkin lymphoma. Based on a large cohort of patients (n=282), Rodrigues and colleagues suggest that the nature of MCL ecosystem could influence tumor progression. They identify several markers, i.e. CD163, FOXP3 and PDL1, which correlate with worse outcome, independent of established risk factors. Their work gives new insights into the nature of MCL ecosystem, especially T-cells and macrophages, and into its role in tumor expansion and resistance.
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https://www.hal.inserm.fr/inserm-03128392
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Submitted on : Tuesday, February 2, 2021 - 11:00:37 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:38 AM
Long-term archiving on: : Monday, May 3, 2021 - 6:25:51 PM

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David Chiron. Commentary on Rodrigues et al : Towards ecosystem integration for a better understanding of B-cell lymphomas aggressiveness. British Journal of Haematology, Wiley, 2021. ⟨inserm-03128392⟩

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