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Uncovering the Role of Glycogen in Brown Adipose Tissue

Abstract : The presence of glycogen in the brown adipose tissue (BAT) has been described 60 years ago. However, the role of this energetic storage in brown adipocytes has been long time underestimated. We have recently shown that during brown adipocyte differentiation in the embryo, glycogen accumulates and is degraded by glycophagy, a dynamic essential for lipid droplets biogenesis. Recent studies have shown that the storage and degradation of triglycerides in BAT are not essential for the activation of BAT in response to cold exposure in adults, and that glycogen can compensate for their absence. In this review, we report the recent advances related to the importance of glycogen in brown adipocytes.
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https://www.hal.inserm.fr/inserm-03121019
Contributor : Marie-Hélène Derudas <>
Submitted on : Tuesday, January 26, 2021 - 9:39:37 AM
Last modification on : Wednesday, January 27, 2021 - 3:14:18 AM

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Alicia Mayeuf-Louchart. Uncovering the Role of Glycogen in Brown Adipose Tissue. Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2021, Online ahead of print. ⟨10.1007/s11095-020-02979-6⟩. ⟨inserm-03121019⟩

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