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Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections

Abstract : Background: Dental cellulitis management is no longer a simple procedure, as more and more patients are needing long-time hospitalization, several surgeries and intensive care follow-up. This prospective study seeks to highlight criteria that can split patients with severe odontogenic infection into two groups: those with simple evolution and those for whom complex management is necessary. Methods: In this observational study, all patients considered with a severe odontogenic infection (which necessitated hospital admission, intravenous antibiotics and general anaesthesia) were enrolled between January 2004 and December 2014 from Clermont-Ferrand University Hospital (France). They were split into two groups: those who needed one surgical intervention with tooth extraction and collection drainage combined with probabilistic antibiotic to treat infection and those who need several surgeries, intensive care unit follow-up or tracheotomy to achieve healing. Results: 653 patients were included, of which 611 (94%) had one surgery, 42 (6%) had more than one surgery before healing. Penicillin allergy (p < 0.001), psychiatric disorders (p = 0.005), oropharyngeal oedema (p = 0.008), floor oedema (p = 0.004), fever (p = 0.04) and trismus (p = 0.018) on admission were the most relevant predictors of complex evolution. A conditional inference tree (CTREE) illustrated the association of prognostic factors and the need of multiple surgery. Conclusions: Besides clinical symptoms of severity, complications of severe odontogenic infection are predicted by measurables and objectives criteria as penicillin allergy, mandibular molar, Creactive protein level, psychiatric disorders and alcohol abuse. Their specific association potentialize the risks. IRB number: CE-CIC-GREN-12-08.
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https://www.hal.inserm.fr/inserm-03112409
Contributor : Radhouane Dallel <>
Submitted on : Saturday, January 16, 2021 - 5:53:29 PM
Last modification on : Tuesday, February 23, 2021 - 1:32:01 PM

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Nathalie Pham Dang, Candice Delbet-Dupas, Aurélien Mulliez, Laurent Devoize, Radhouane Dallel, et al.. Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections. International Journal of Environmental Research and Public Health, MDPI, 2020, 17 (23), pp.8917. ⟨10.3390/ijerph17238917⟩. ⟨inserm-03112409⟩

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