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Relations between influenza, dengue outbreaks, and subsequent bacterial sepsis in French Guiana: a time series analysis

Abstract : Objective : Infuenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of in uenza epidemics is less marked and this may not be the case. Dengue is often followed by prolonged asthenia and some physicians hypothesized increased susceptibility to infections based on anecdotal observations. Time series of in uenza and dengue surveillance were confronted with bacterial sepsis admissions to test the hypotheses. Monthly surveillance data on in uenza and dengue and aggregated sepsis data in Cayenne hospital were matched between 24/10/2007 and 27/09/2016. An ARIMA (1,0,1) model was used. Results : The series of the number of monthly cases of sepsis was positively associated with the monthly number of cases of in uenza at time t (β=0.001, p=0.0359). Forecasts were imperfectly correlated with sepsis since in uenza is not the only risk factor for sepsis. None of the ARIMA models showed a signi cant link between the dengue series and the sepsis series. There was thus no link between dengue epidemics and sepsis but it was estimated that for every 1000 cases of u there was one additional case of sepsis. In this tropical setting, in uenza was highly seasonal, and improved vaccination coverage could have bene ts on sepsis.
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Preprints, Working Papers, ...
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https://www.hal.inserm.fr/inserm-03098530
Contributor : Christine Dupuis <>
Submitted on : Tuesday, January 5, 2021 - 5:59:11 PM
Last modification on : Wednesday, January 6, 2021 - 11:23:29 AM
Long-term archiving on: : Wednesday, April 7, 2021 - 9:27:19 AM

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Claire Cropet, Philippe Abboud, Emilie Mosnier, Loïc Epelboin, Félix Djossou, et al.. Relations between influenza, dengue outbreaks, and subsequent bacterial sepsis in French Guiana: a time series analysis. 2021. ⟨inserm-03098530⟩

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