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Journal articles
Covid-19 and blood groups: ABO antibody levels may also matter
Marie Deleers
1, 2
Adrien Breiman
3
Valéry Daubie
2
Carine Maggetto
1, 2
Isabelle Barreau
1, 2
Tatiana Besse
1, 2
Béatrice Clémenceau
4
Nathalie Ruvoën-Clouet
3
Jean-François Fils
5
Evelyne Maillart
1, 2
Virginie Doyen
1, 2
Bhavna Mahadeb
2
Jacques Jani
1, 2
Philippe Der Linden
1, 2
Mieke Cannie
1, 2
Nabil Hayef
1, 2
Francis Corazza
1, 2
Jacques Le Pendu
3
Hanane Kenz
1, 2
3
CRCINA-ÉQUIPE 5 - Host-Pathogen Interactions in the Regulation of Immune Responses
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
4
CRCINA-ÉQUIPE 1 - Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Marie Deleers 1, 2
Author
Adrien Breiman 3
Author
Valéry Daubie 2
Author
Carine Maggetto 1, 2
Author
Isabelle Barreau 1, 2
Author
Tatiana Besse 1, 2
Author
Béatrice Clémenceau 4
Author
Nathalie Ruvoën-Clouet 3
Author
Jean-François Fils 5
Author
Evelyne Maillart 1, 2
Author
Virginie Doyen 1, 2
Author
Bhavna Mahadeb 2
Author
Jacques Jani 1, 2
Author
Philippe Van Der Linden 1, 2
Author
Mieke Cannie 1, 2
Author
Nabil Hayef 1, 2
Author
1
CHU - Centre Hospitalier Universitaire Brugmann [Bruxelles] (Place A.Van Gehuchten 4, 1020 Bruxelles - Belgium)
2
ULB - Université libre de Bruxelles (Avenue Franklin Roosevelt 50 - 1050 Bruxelles - Belgium)
3
CRCINA-ÉQUIPE 5 - Host-Pathogen Interactions in the Regulation of Immune Responses (Institut de Recherche en Santé 2 de l'Université de Nantes, 22 Boulevard Bénoni Goullin, 44200 Nantes - France)
- CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (8 quai de Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR1232 (101, rue de Tolbiac, 75013 Paris - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales : UMR1232 (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes : UMR1232 (1 Place Alexis-Ricordeau, 44000 Nantes - France)
- CNRS - Centre National de la Recherche Scientifique : ERL6001 (France)
- UA - Université d'Angers : UMR1232 (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
4
CRCINA-ÉQUIPE 1 - Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (Institut de Recherche en Santé de l'Université de Nantes - 8 quai Moncousu - BP 70721 - 44007 Nantes cedex 1 - France)
- CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (8 quai de Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR1232 (101, rue de Tolbiac, 75013 Paris - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales : UMR1232 (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes : UMR1232 (1 Place Alexis-Ricordeau, 44000 Nantes - France)
- CNRS - Centre National de la Recherche Scientifique : ERL6001 (France)
- UA - Université d'Angers : UMR1232 (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
5
Ars Statistica [Nivelles, Belgium] (Belgium)
Abstract : Background : Susceptibility to Covid-19 has been found to be associated with ABO blood group, with O type individuals being at a lower risk. However, the underlying mechanism has not been elucidated. Here, we aimed to test the hypothesis that Covid-19 patients might have lower levels of ABO antibodies than non-infected individuals as they could offer some degree of protection.
Methods : After showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies.
Results : We found significantly lower IgM anti-A + anti-B agglutination scores in blood group O patients (76.93 vs 88.29, P-value=0.034) and lower levels of anti-B (24.93 vs 30.40, P-value=0.028) and anti-A antibodies (28.56 vs 36.50, P-value= 0.048) in blood group A and blood group B patients, respectively, compared to controls.
Conclusion : In this study, we showed that ABO antibodies levels are significantly lower in Covid-19 patients compared to controls. These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected.
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Journal articles
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https://www.hal.inserm.fr/inserm-03094253
Contributor : Elizabeth Bernardo <>
Submitted on : Monday, January 4, 2021 - 11:47:44 AM
Last modification on : Tuesday, January 19, 2021 - 9:28:25 AM
Contributor : Elizabeth Bernardo <>
Submitted on : Monday, January 4, 2021 - 11:47:44 AM
Last modification on : Tuesday, January 19, 2021 - 9:28:25 AM
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Identifiers
- HAL Id : inserm-03094253, version 1
- DOI : 10.1016/j.ijid.2020.12.025
- PUBMED : 33326874
Collections
INSERM | CRCINA | UNIV-NANTES | UNIV-ANGERS | CNRS
Citation
Marie Deleers, Adrien Breiman, Valéry Daubie, Carine Maggetto, Isabelle Barreau, et al.. Covid-19 and blood groups: ABO antibody levels may also matter. International Journal of Infectious Diseases, Elsevier, 2020, pp.S1201-9712(20)32549-2. ⟨10.1016/j.ijid.2020.12.025⟩. ⟨inserm-03094253⟩
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