Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials - Archive ouverte HAL Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2020

Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials

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Abstract

A series of 4-aminoquinoline-isoindoline-dione-isoniazid triads were synthesized and assessed for their anti-mycobacterial activities and cytotoxicity. Most of the synthesized compounds exhibited promising activities against the mc26230 strain of M. tuberculosis with MIC in the range of 3.125-12.5 µg/mL and were non-cytotoxic against Vero cells. The conjugates lacking either isoniazid or quinoline core in their structural framework failed to inhibit the growth of M. tuberculosis; thus, further strengthening the proposed design of triads in the present study.
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Dates and versions

inserm-03082751 , version 1 (18-12-2020)

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Anu Rani, Matt Johansen, Françoise Roquet-Banères, Laurent Kremer, Paul Awolade, et al.. Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials. Bioorganic and Medicinal Chemistry Letters, 2020, 30 (22), pp.127576. ⟨10.1016/j.bmcl.2020.127576⟩. ⟨inserm-03082751⟩
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